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Centenarian blood tests give hints of the secrets to longevity

<a href="https://theconversation.com/profiles/karin-modig-1473484">Karin Modig</a>, <a href="https://theconversation.com/institutions/karolinska-institutet-1250">Karolinska Institutet</a> Centenarians, once considered rare, have become commonplace. Indeed, they are the <a href="https://www.weforum.org/agenda/2021/02/living-to-one-hundred-life-expectancy/">fastest-growing demographic group</a> of the world’s population, with numbers roughly doubling every ten years since the 1970s. How long humans can live, and what determines a long and healthy life, have been of interest for as long as we know. Plato and Aristotle discussed and <a href="https://pubmed.ncbi.nlm.nih.gov/12092789/">wrote about the ageing process</a> over 2,300 years ago. The pursuit of understanding the secrets behind exceptional longevity isn’t easy, however. It involves <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7105197/">unravelling the complex interplay</a> of genetic predisposition and lifestyle factors and how they interact throughout a person’s life. Now our recent study, <a href="https://link.springer.com/article/10.1007/s11357-023-00936-w">published in GeroScience</a>, has unveiled some common biomarkers, including levels of cholesterol and glucose, in people who live past 90. Nonagenarians and centenarians have long been of intense interest to scientists as they may help us understand how to live longer, and perhaps also how to age in better health. So far, studies of centenarians have often been small scale and focused on a selected group, for example, excluding centenarians who live in care homes. <h2>Huge dataset</h2> Ours is the largest study comparing biomarker profiles measured throughout life among exceptionally long-lived people and their shorter-lived peers to date. We compared the biomarker profiles of people who went on to live past the age of 100, and their shorter-lived peers, and investigated the link between the profiles and the chance of becoming a centenarian. Our research included data from 44,000 Swedes who underwent health assessments at ages 64-99 - they were a sample of <a href="https://pubmed.ncbi.nlm.nih.gov/28158674/">the so-called Amoris cohort</a>. These participants were then followed through Swedish register data for up to 35 years. Of these people, 1,224, or 2.7%, lived to be 100 years old. The vast majority (85%) of the centenarians were female. Twelve blood-based biomarkers related to inflammation, metabolism, liver and kidney function, as well as potential malnutrition and anaemia, were included. All of these <a href="https://www.nature.com/articles/s41591-019-0719-5">have been associated</a> with ageing or mortality in previous studies. The biomarker related to inflammation was uric acid – a waste product in the body caused by the digestion of certain foods. We also looked at markers linked to metabolic status and function including total cholesterol and glucose, and ones related to liver function, such as alanine aminotransferase (Alat), aspartate aminotransferase (Asat), albumin, gamma-glutamyl transferase (GGT), alkaline phosphatase (Alp) and lactate dehydrogenase (LD). We also looked at creatinine, which is linked to kidney function, and iron and total iron-binding capacity (TIBC), which is linked to anaemia. Finally, we also investigated albumin, a biomarker associated with nutrition. <h2>Findings</h2> We found that, on the whole, those who made it to their hundredth birthday tended to have lower levels of glucose, creatinine and uric acid from their sixties onwards. Although the median values didn’t differ significantly between centenarians and non-centenarians for most biomarkers, centenarians seldom displayed extremely high or low values. For example, very few of the centenarians had a glucose level above 6.5 earlier in life, or a creatinine level above 125. For many of the biomarkers, both centenarians and non-centenarians had values outside of the range considered normal in clinical guidelines. This is probably because these guidelines are set based on a younger and healthier population. When exploring which biomarkers were linked to the likelihood of reaching 100, we found that all but two (alat and albumin) of the 12 biomarkers showed a connection to the likelihood of turning 100. This was even after accounting for age, sex and disease burden. The people in the lowest out of five groups for levels of total cholesterol and iron had a lower chance of reaching 100 years as compared to those with higher levels. Meanwhile, people with higher levels of glucose, creatinine, uric acid and markers for liver function also decreased the chance of becoming a centenarian. In absolute terms, the differences were rather small for some of the biomarkers, while for others the differences were somewhat more substantial. For uric acid, for instance, the absolute difference was 2.5 percentage points. This means that people in the group with the lowest uric acid had a 4% chance of turning 100 while in the group with the highest uric acid levels only 1.5% made it to age 100. Even if the differences we discovered were overall rather small, they suggest a potential link between metabolic health, nutrition and exceptional longevity. The study, however, does not allow any conclusions about which lifestyle factors or genes are responsible for the biomarker values. However, it is reasonable to think that factors such as nutrition and alcohol intake play a role. Keeping track of your kidney and liver values, as well as glucose and uric acid as you get older, is probably not a bad idea. That said, chance probably plays a role at some point in reaching an exceptional age. But the fact that differences in biomarkers could be observed a long time before death suggests that genes and lifestyle may also play a role.<img style="border: none !important; box-shadow: none !important; margin: 0 !important; max-height: 1px !important; max-width: 1px !important; min-height: 1px !important; min-width: 1px !important; opacity: 0 !important; outline: none !important; padding: 0 !important;" src="https://counter.theconversation.com/content/215166/count.gif?distributor=republish-lightbox-basic" alt="The Conversation" width="1" height="1" /> <a href="https://theconversation.com/profiles/karin-modig-1473484">Karin Modig</a>, Associate Professor, Epidemiology, <a href="https://theconversation.com/institutions/karolinska-institutet-1250">Karolinska Institutet</a> Image credits: Shutterstock This article is republished from <a href="https://theconversation.com">The Conversation</a> under a Creative Commons license. Read the <a href="https://theconversation.com/centenarian-blood-tests-give-hints-of-the-secrets-to-longevity-215166">original article</a>.

Retirement Life

8 reasons everyone should know their blood type

Why you should know your blood type What’s in a blood type? Potentially a lot, according to research, including a review of studies published in the Wiley Interdisciplinary Reviews: Systems Biology and Medicine, that connects different blood groups to everything from risk of heart disease and dementia to urinary tract infections and the norovirus. While none of the studies are conclusive about cause and effect (they can’t say X blood type causes Y disease) and any increased risks are still pretty small, the research does highlight the importance of knowing your type – A, B, AB, or O – and how it could affect your wellbeing. Blood clots: Type AB, A, and B increases risk Danish researchers studied how blood type interacts with a genetic predisposition for deep-vein thrombosis (DVT), or blood clots in the lower legs that can travel to the lungs and become life-threatening. After analysing data on about 66,000 people over more than 30 years, they found that those with type AB, A, or B had a 40 per cent higher risk of DVT than people with type O, the most common type. When the scientists did further analysis to see which factors have the biggest impact on DVT risk on a population level, they found that an AB blood type contributed to about 20 per cent of blood clots; genetic mutations accounted for 11 per cent, being overweight accounted for 16 per cent, and smoking accounted for six per cent. Heart disease: Type AB, B, and A all increase risk People whose blood type is A, B, or AB have an increased risk of heart disease and shorter life spans than people who have type O blood, according to a large study published in BMC Medicine. After following more than 50,000 middle-age and elderly people for seven years, on average, researchers found that as many as nine per cent of cardiovascular deaths were attributed to having non-O blood types. However, as any doctor will tell you, lifestyle factors like weight, smoking and diet, which, unlike blood type, are modifiable, have a much greater impact on heart disease. Stomach cancer: Types A and AB increases risk Researchers have known for a while that people with blood type A are at risk for stomach cancer. But research published in BMC Cancer shows that people with blood type AB are also at risk. Using genetic data from a large number of cases and controls, researchers found a link between both blood types and gastric cancer in Chinese populations. A review of 39 previous studies confirmed their findings. Fertility: Type O reduces it Women with this blood type were twice as likely to have blood levels of the hormone FSH high enough to indicate low ovarian reserve, a measure of fertility, according to a study published in Human Reproduction. Researchers couldn’t say for sure why, though. Given that type O blood is the most prevalent, it doesn’t pay to worry too much about it. Age is a far more important risk factor for fertility problems. Pregnancy risks This has nothing to do with your “letter” blood type or the type determined by the ABO grouping system. This has to do with what’s known as the Rhesus (Rh) factor, which determines whether your blood type is positive or negative. This could cause complications in pregnant women if the baby’s Rh blood type is different from the mother’s. For instance, if the mother has a negative blood type and the baby has a positive one, the mother’s body can actually build up antibodies against the baby’s blood type. Luckily, this doesn’t affect the baby, but it could have a negative effect on future pregnancies. Fortunately, doctors can give pregnant women a shot early in their pregnancy that can prevent Rh-incompatibility problems. Dementia and memory loss: Type AB increases risk People with type AB blood have an 82 per cent greater risk for cognitive decline later in life, according to a study published in Neurology. That’s likely because they have larger amounts of what’s known as the Factor VIII protein, which helps with blood clotting. Study participants with higher levels of this protein were 24 per cent more likely to develop memory problems – regardless of their blood type – than people with lower levels. Blood type, however, is far from the only, or even most important, factor that affects your risk for cognitive decline. Stroke: Type O has the lowest risk People with a blood type other than O (the most common) have a higher risk of cardiovascular issues such as stroke, according to a study published in the Journal of Thrombosis and Haemostasis. Biologists are still investigating why this might be; one possible explanation is that non-O blood types contain more of the Von Willebrand factor, a protein that has been connected to blood clotting and stroke in the past. Mosquitos like Type O blood If you find yourself scratching bug bites all summer long, your blood type might be to blame. In a one small study, researchers found that type Os are up to twice as attractive to mosquitoes as type As, with type Bs falling somewhere in the middle. Image credits: Shutterstock This article originally appeared on <a href="https://www.readersdigest.co.nz/healthsmart/8-reasons-everyone-should-know-their-blood-type" target="_blank" rel="noopener">Reader's Digest</a>.

Body

Worried about getting a blood test? 5 tips to make them easier (and still accurate)

<a href="https://theconversation.com/profiles/sapha-shibeeb-1481231">Sapha Shibeeb</a>, <a href="https://theconversation.com/institutions/rmit-university-1063">RMIT University</a> Blood tests are a common medical procedure, offering valuable insights into a person’s health. Whether you’re getting a routine check-up, diagnosing a medical condition or monitoring treatment progress, understanding the process can make the experience more comfortable and effective. For the majority of patients, blood collections are a minor inconvenience. Others may feel <a href="https://www.sciencedirect.com/science/article/abs/pii/S0887618506000041">uneasy and anxious</a>. Preparation strategies can help get you through the procedure. <h2>How blood is collected</h2> During venipuncture (blood draw), the phlebotomist (blood collector) inserts a needle through the skin into a vein and a small amount of blood is collected and transferred into a test tube. Tubes are sent to a laboratory, where the blood is analysed. A laboratory technician may count or examine cells and measure the levels of minerals/salts, enzymes, proteins or other substances in the sample. For some tests, blood plasma is separated out by spinning (centrifuging) the sample. Others pass a light beam through the sample to determine the amount of a chemical present. For collection, the phlebotomist usually selects a vein in the crook of your elbow, where veins are readily accessible. Blood can also be drawn from veins in the wrists, fingers or heels. A tourniquet may be applied to restrict blood flow and make the chosen vein puff out. <h2>Different tests require different preparation</h2> Before a blood test, the GP or health-care provider will give you specific instructions. These may include fasting for up to 12 hours or temporarily discontinuing certain medications. It is crucial to follow these guidelines meticulously as they can significantly impact the accuracy of your test results. For example, fasting is required before glucose (blood sugar) and lipids (blood fats) testing because blood sugar and cholesterol levels typically increase after a meal. If the blood test requires fasting, you will be asked not to eat or drink (no tea, coffee, juice or alcohol) for about eight to 12 hours. Water is allowed but smoking should be avoided because it can increase <a href="https://diabetesjournals.org/care/article/19/2/112/19825/Acute-Effect-of-Cigarette-Smoking-on-Glucose">blood sugar, cholesterol and triglyceride levels</a>. Generally, you will be asked to fast overnight and have the blood collection done in the morning. Fasting for longer than 15 hours could impact your results, too, by causing dehydration or the release of certain chemicals in the blood. If you have diabetes, you must consult your doctor prior to fasting because it can increase the risk of hypoglycemia (low blood sugar) in people with type 1 diabetes. Most type 2 diabetics can safely fast before a blood test but there are some exceptions, such as people who are taking certain medications including insulin. <h2>5 tips for a better blood test</h2> To improve your blood collection experience, consider these tips: 1. Hydrate Drink plenty of water right up to 30 minutes before your appointment. Adequate hydration improves blood flow, making your veins more accessible. Avoid <a href="https://academic.oup.com/labmed/article/34/10/736/2657269">strenuous exercise</a> before your blood test, which can increase some blood parameters (such as liver function) while decreasing others (such as sodium). 2. Loose clothing Wear clothing that allows easy access to your arms to ensure a less stressful procedure. 3. Manage anxiety If the sight of blood or the procedure makes you anxious, look away while the needle is inserted and try to keep breathing normally. Distraction can help – virtual reality has been <a href="https://pubmed.ncbi.nlm.nih.gov/31889358/">trialled</a> to reduce needle anxiety in children. You could try bringing something to read or music to listen to. 4. Know your risk of fainting If you’re prone to fainting, make sure to inform the phlebotomist when you arrive. You can have your blood drawn while lying down to minimise the risk of passing out and injury. Hydration helps maintain blood pressure and can also <a href="https://www.ahajournals.org/doi/10.1161/01.CIR.0000101966.24899.CB">reduce the risk</a> of fainting. 5. Discuss difficult veins Some people have smaller or scarred veins, often due to repeated punctures, <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4989034/">chemotherapy</a> or blood thinner use. In such cases, venipuncture may require multiple attempts. It is important to talk to the phlebotomist if you feel discomfort or significant pain. A finger prick can be performed as an alternative for some tests, such as blood glucose levels. But other comprehensive tests require larger blood volume. <h2>Blood draws after lymph node removal</h2> Historically, there were concerns about drawing blood from an arm that had undergone lymph node removal. This was due to the risk of <a href="https://www.cancer.gov/about-cancer/treatment/side-effects/lymphedema/lymphedema-pdq#:%7E:text=Lymphedema%20is%20the%20build%2Dup,the%20way%20that%20it%20should.">lymphedema</a>, a condition marked by fluid build-up in the affected arm. Lymph nodes may have been removed (<a href="https://www.ncbi.nlm.nih.gov/books/NBK564397/#:%7E:text=Lymph%20node%20dissection%2C%20also%20known,surgical%20management%20of%20malignant%20tumors.">lymphadenectomy</a>) for cancer diagnosis or treatment. However, a <a href="https://ascopubs.org/doi/10.1200/JCO.2015.61.5948">2016 study</a> showed people who’ve had lymph nodes removed are not at a higher risk of developing lymphedema following blood draws, even when drawing blood from the affected arm. <h2>After your blood test</h2> The whole blood test procedure usually lasts no more than a few minutes. Afterwards, you may be asked to apply gentle pressure over a clean dressing to aid clotting and reduce swelling. If you do experience swelling, bruising or pain after a test, follow general first aid procedures to alleviate discomfort. These include applying ice to the site, resting the affected arm and, if needed, taking a pain killer. It is usually recommended you do not do heavy lifting for a few hours after a blood draw. This is to prevent surges in blood flow that could prevent clotting where the blood was taken.<img style="border: none !important; box-shadow: none !important; margin: 0 !important; max-height: 1px !important; max-width: 1px !important; min-height: 1px !important; min-width: 1px !important; opacity: 0 !important; outline: none !important; padding: 0 !important;" src="https://counter.theconversation.com/content/216073/count.gif?distributor=republish-lightbox-basic" alt="The Conversation" width="1" height="1" /> <a href="https://theconversation.com/profiles/sapha-shibeeb-1481231">Sapha Shibeeb</a>, Senior lecturer in Laboratory Medicine , <a href="https://theconversation.com/institutions/rmit-university-1063">RMIT University</a> Image credits: Shutterstock This article is republished from <a href="https://theconversation.com">The Conversation</a> under a Creative Commons license. Read the <a href="https://theconversation.com/worried-about-getting-a-blood-test-5-tips-to-make-them-easier-and-still-accurate-216073">original article</a>.

Body

No, you can’t reverse ageing by injecting ‘young blood’ and fasting. But that doesn’t stop people trying

<a href="https://theconversation.com/profiles/rachael-jefferson-buchanan-297850">Rachael Jefferson-Buchanan</a>, <a href="https://theconversation.com/institutions/charles-sturt-university-849">Charles Sturt University</a> Like many celebrities and entrepreneurs, 45-year-old US tech billionaire Bryan Johnson is <a href="https://www.smh.com.au/lifestyle/health-and-wellness/taking-the-blood-of-your-17-year-old-son-anti-ageing-has-gone-too-far-20230530-p5dcd6.html">trying to reverse the ageing process</a>. Spending an average of US$2 million a year on an anti-ageing regimen, Johnson <a href="https://medium.com/future-literacy/at-45-i-now-age-slower-than-the-average-10-year-old-6932448fc608">claims</a> he now ages slower than some children. He explains: “the pace my body accumulates ageing damage is less than the average ten year old”. Many of Johnson’s age-reversal methods are questionable, involve dodgy science, and have known side effects. While you can’t stop the ageing process, and the gradual decline our bodies experience as we advance in years, there are some things we can all do – for free – to maintain our health as we age. <h2>What does Johnson do? And is it scientific?</h2> Fasting Johnson reports fasting for 23 hours a day. He then eats <a href="https://medium.com/future-literacy/one-meal-23-hr-fast-100-nutrition-18187a2f5b">one meal a day</a>: 2,250 calories of nutrient-dense food “customised” to his body’s needs. Eating for time-restricted periods in the day can have a <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9650338/">positive effect</a> on how we <a href="https://pubmed.ncbi.nlm.nih.gov/29955217/">metabolise nutrients</a>, inflammation levels, hormonal regulation, and <a href="https://www.health.harvard.edu/blog/how-good-is-your-cardiometabolic-health-and-what-is-that-anyway-202208182803">cardiometabolic health</a> (blood sugar, <a href="https://www.mayoclinic.org/diseases-conditions/high-blood-cholesterol/in-depth/triglycerides/art-20048186">triglycerides</a>, cholesterol, blood pressure, BMI and waist circumference). However, a Spartan-like food intake can <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2121099/">impair</a> how our body responds to sugar (known as glucose tolerance). And it’s not necessarily any more effective for weight maintenance than <a href="https://pubmed.ncbi.nlm.nih.gov/29419624/">reducing calorie intake at each meal</a>. Large-scale, long-term human trials are needed to confirm the <a href="https://pubmed.ncbi.nlm.nih.gov/34728336/">limited risk-benefit</a> findings of fasting. Acid peels Johnson has weekly <a href="https://www.asds.net/skin-experts/skin-treatments/chemical-peels/chemical-peels-for-aging-skin">acid peels</a> (which use a mild acid to exfoliate the skin) to maintain a “youthful glow”. But you cannot smooth sagging facial skin or remove deep scars or wrinkles. Acid peels also <a href="https://www.mayoclinic.org/tests-procedures/chemical-peel/about/pac-20393473">come with risks</a>, including organ damage, infection, scarring and swelling. Plasma infusions Perhaps the most bizarre youth-inducing procedure Johnson has attempted is receiving blood transfusions from his 17-year-old son. US biotech companies have explored <a href="https://www.theguardian.com/society/2020/feb/02/could-young-blood-stop-us-getting-old-transfusions-experiments-mice-plasma">plasma infusions</a> to tackle age-related diseases in humans for decades. But there are no proven clinical benefits. <a href="https://www.redcrossblood.org/donate-blood/blood-donation-process/what-happens-to-donated-blood/blood-transfusions/risks-complications.html">Side effects from blood transfusions</a> include blood-borne infections, fever and allergic reactions. <h2>Historical attempts to stay youthful</h2> Humans have been experimenting with <a href="https://academic.oup.com/biomedgerontology/article/59/6/B515/662071">anti-ageing methods for centuries</a>. These have included all sorts of behavioural and lifestyle practices that are quirky, questionable, and even sadistic. Ancient practices included <a href="https://www.marieclaire.com/beauty/news/a14382/anti-aging-beauty-through-history/">crocodile dung face masks</a>, which the Greeks and Romans used to brighten their complexions. Romans also used <a href="https://beautytap.com/2019/03/donkey-milk">donkey milk</a> and <a href="https://www.ancient-origins.net/history/swans-fat-crocodile-dung-and-ashes-snails-achieving-beauty-ancient-rome-003240">swan fat</a> to minimise wrinkles, due to their acclaimed rejuvenating properties. <a href="https://www.livescience.com/44071-cleopatra-biography.html">Cleopatra</a> apparently took daily baths in sour donkey milk. To sustain this lavish habit, she had a <a href="https://www.naturanecosmetics.com/en/content/26-faits-historiques">herd of 700 donkeys</a>. Sour milk contains <a href="https://science.jrank.org/pages/3780/Lactic-Acid-Lactic-acid-in-foods.html">lactic acid</a>, a naturally occurring <a href="https://www.mecca.com.au/edits/ingredients/alpha-hydroxy-acids/">alpha-hydroxy acid (AHA)</a> that exists in many modern-day exfoliants. So this idea was grounded in basic science, at least. <figure class="align-center "><img src="https://images.theconversation.com/files/530478/original/file-20230607-27-bv0w1t.jpg?ixlib=rb-1.1.0&q=45&auto=format&w=754&fit=clip" sizes="(min-width: 1466px) 754px, (max-width: 599px) 100vw, (min-width: 600px) 600px, 237px" srcset="https://images.theconversation.com/files/530478/original/file-20230607-27-bv0w1t.jpg?ixlib=rb-1.1.0&q=45&auto=format&w=600&h=400&fit=crop&dpr=1 600w, https://images.theconversation.com/files/530478/original/file-20230607-27-bv0w1t.jpg?ixlib=rb-1.1.0&q=30&auto=format&w=600&h=400&fit=crop&dpr=2 1200w, https://images.theconversation.com/files/530478/original/file-20230607-27-bv0w1t.jpg?ixlib=rb-1.1.0&q=15&auto=format&w=600&h=400&fit=crop&dpr=3 1800w, https://images.theconversation.com/files/530478/original/file-20230607-27-bv0w1t.jpg?ixlib=rb-1.1.0&q=45&auto=format&w=754&h=503&fit=crop&dpr=1 754w, https://images.theconversation.com/files/530478/original/file-20230607-27-bv0w1t.jpg?ixlib=rb-1.1.0&q=30&auto=format&w=754&h=503&fit=crop&dpr=2 1508w, https://images.theconversation.com/files/530478/original/file-20230607-27-bv0w1t.jpg?ixlib=rb-1.1.0&q=15&auto=format&w=754&h=503&fit=crop&dpr=3 2262w" alt="Milk bath with dried fruits and flowers" /><figcaption>Don’t waste milk on a bath. <a class="source" href="https://www.shutterstock.com/image-photo/bath-milk-flowers-1051210370">Shutterstock</a></figcaption></figure> During the 16th and 17th century, “Countess Dracula” aka <a href="https://en.wikipedia.org/wiki/Elizabeth_B%C3%A1thory">Elizabeth Bathory</a> allegedly resorted to serial killing to quench her thirst for youthfulness, <a href="https://www.nationalgeographic.com/travel/article/the-bloody-legend-of-hungarys-serial-killer-countess">bathing in the blood of her young victims</a>. <h2>The quest continues with cryotherapy</h2> Fountain of youth fixations have inspired many contemporary anti-ageing trends. Exposure to cold is a firm favourite. <a href="https://www.nature.com/articles/s43587-023-00383-4">Some research</a> suggests this could have <a href="https://neurosciencenews.com/cold-aging-22928/">benefits</a> relating to longevity, by slowing cellular degeneration, <a href="https://www.cryo.com.au/anti-ageing-benefits-of-whole-body-cryotherapy/">stimulating collagen and elastin production</a>, increasing the metabolism, and reducing inflammation. Dutch motivational speaker Wim Hof includes <a href="https://www.wimhofmethod.com/cold-water-immersion">cold water immersion</a> as one of the three pillars of his <a href="https://www.wimhofmethod.com/">Wim Hof Method</a> to “increase mind-body connection”. Athletes such as <a href="https://www.dailymail.co.uk/sport/football/article-2469985/Cristiano-Ronaldo-buys-Cryotherapy-chamber.html">Cristiano Ronaldo</a> use <a href="https://my.clevelandclinic.org/health/treatments/21099-cryotherapy">cryotherapy</a>, exposing their bodies to extremely cold temperatures for two to four minutes to decrease the signs of ageing and enhance their general health. However, the <a href="https://www.medicinenet.com/what_are_the_side_effects_of_cryotherapy/article.htm">risks of cryotherapy</a> include bone fractures, frostbite, nerve damage, bleeding, cramping, swelling and skin infections. <h2>So what can we do to age well?</h2> Two of the more mainstream anti-ageing methods that Johnson recommends are the daily self-care habits of sleep and exercise. He has a <a href="https://medium.com/future-literacy/sleep-and-impulse-control-87e844218ff2">strict sleep schedule</a> that involves retiring to bed at 8pm, with a one-hour wind-down in a darkened room. Adults report poorer sleep quality and difficulty being able to sleep for long enough <a href="https://www.news-medical.net/health/How-Does-the-Suprachiasmatic-Nucleus-(SCN)-Control-Circadian-Rhythm.aspx">as they age</a>. Sleeping too much or too little is <a href="https://www.frontiersin.org/articles/10.3389/fpubh.2023.1043347/full">associated with</a> a greater risk of obesity, heart disease and <a href="https://theconversation.com/research-check-can-sleeping-too-much-lead-to-an-early-death-101323">premature death</a>. Developing a regular sleep routine, reducing bedroom distractions such as mobile phones, and exercising regularly can all help to <a href="https://www.sleepfoundation.org/aging-and-sleep">alleviate sleep problems</a>. <figure class="align-center "><img src="https://images.theconversation.com/files/530491/original/file-20230607-29-cw0f29.jpg?ixlib=rb-1.1.0&q=45&auto=format&w=754&fit=clip" sizes="(min-width: 1466px) 754px, (max-width: 599px) 100vw, (min-width: 600px) 600px, 237px" srcset="https://images.theconversation.com/files/530491/original/file-20230607-29-cw0f29.jpg?ixlib=rb-1.1.0&q=45&auto=format&w=600&h=383&fit=crop&dpr=1 600w, https://images.theconversation.com/files/530491/original/file-20230607-29-cw0f29.jpg?ixlib=rb-1.1.0&q=30&auto=format&w=600&h=383&fit=crop&dpr=2 1200w, https://images.theconversation.com/files/530491/original/file-20230607-29-cw0f29.jpg?ixlib=rb-1.1.0&q=15&auto=format&w=600&h=383&fit=crop&dpr=3 1800w, https://images.theconversation.com/files/530491/original/file-20230607-29-cw0f29.jpg?ixlib=rb-1.1.0&q=45&auto=format&w=754&h=482&fit=crop&dpr=1 754w, https://images.theconversation.com/files/530491/original/file-20230607-29-cw0f29.jpg?ixlib=rb-1.1.0&q=30&auto=format&w=754&h=482&fit=crop&dpr=2 1508w, https://images.theconversation.com/files/530491/original/file-20230607-29-cw0f29.jpg?ixlib=rb-1.1.0&q=15&auto=format&w=754&h=482&fit=crop&dpr=3 2262w" alt="Child and grandfather walk on a beach" /><figcaption>Exercise is also important for healthy ageing. <a class="source" href="https://unsplash.com/photos/s-vhziQHngM">Vidar Nordi Mathisen/Unsplash</a></figcaption></figure> Exercise, often cited as a <a href="https://www.marketwatch.com/story/exercise-is-the-wonder-drug-for-healthy-aging-11633642719">wonder drug for healthy ageing</a>, is something Johnson takes very seriously. He does a “<a href="https://www.youtube.com/watch?v=HNywRJgCRaQ">Blueprint</a>” workout that includes specially designed daily techniques, as well as <a href="https://www.hsph.harvard.edu/nutritionsource/high-intensity-interval-training/">high-intensity interval training sessions</a>, hiking and playing sport. From middle age onwards, we all need to exercise regularly, to increase our muscle mass, bone density, strength, endurance, coordination and balance. One of the greatest health risks for older people is <a href="https://www.ncbi.nlm.nih.gov/books/NBK560761/">falling</a>, which balance, flexibility, endurance and strength training <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC381224/">can help</a> reduce. Physical activity can bring <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5408452/">social benefits</a> in older adults if undertaken in groups, and there are well-known <a href="https://www.whiddon.com.au/yourlife/the-mental-health-benefits-of-exercise-for-older-adults/">mental health gains</a>. Small changes in sleep, diet (eating <a href="https://health.gov/news/202107/nutrition-we-age-healthy-eating-dietary-guidelines">plenty of vegetables, fruit, wholegrains, healthy fats, and enough protein</a>), and exercise can support <a href="https://bmcgeriatr.biomedcentral.com/articles/10.1186/s12877-020-01900-5">healthy ageing</a>, reducing the chance of early death, and helping us all to lead an active and independent life in our senior years. Now that is something worth investing in.<img style="border: none !important; box-shadow: none !important; margin: 0 !important; max-height: 1px !important; max-width: 1px !important; min-height: 1px !important; min-width: 1px !important; opacity: 0 !important; outline: none !important; padding: 0 !important;" src="https://counter.theconversation.com/content/207038/count.gif?distributor=republish-lightbox-basic" alt="The Conversation" width="1" height="1" /> <a href="https://theconversation.com/profiles/rachael-jefferson-buchanan-297850">Rachael Jefferson-Buchanan</a>, Lecturer in Human Movement Studies (Health and PE) and Creative Arts, <a href="https://theconversation.com/institutions/charles-sturt-university-849">Charles Sturt University</a> This article is republished from <a href="https://theconversation.com">The Conversation</a> under a Creative Commons license. Read the <a href="https://theconversation.com/no-you-cant-reverse-ageing-by-injecting-young-blood-and-fasting-but-that-doesnt-stop-people-trying-207038">original article</a>. Images: Getty

Body

Evidence that human evolution driven by major environmental pressures discovered

The genes of ancient humans might have changed substantially due to environmental pressures and change, say an international team of researchers. A widely held belief related to human evolution is that our ancient ancestors’ ability to fashion tools, shelter, and use advanced communication skills may have helped to shield them from large environmental impacts such as changing climate, disease and exposure to other events affecting mortality. But research led out of Australian Centre for Ancient DNA at the University of Adelaide suggests that beneficial genes may have played a more important role in preserving our ancestors. Until now, the sudden increase in frequency of these genes in human groups was masked by the exchange of DNA between people during reproduction. Now, analyses of more than one thousand ancient genomes dating as far back as 45,000 years ago have found historic signals showing genetic adaptation was more common than previously thought. The study of evolutionary events, says the study’s co-lead author Dr Yassine Souilmi, has increased substantially in recent years, as these are the points where human genetics take historic turns. “Evolutionary events [are] exactly what shape our genetic diversity today,” Souilmi tells Cosmos. “That’s what makes us vulnerable to certain diseases [and] resistant to others. “Having a good understanding of evolution, we can have a better understanding of who we are.” Previous research by the Centre has uncovered a range of evolutionary trends, from historic climate change causing the demise of ancestral lions and bears, to the first interactions between humans and coronaviruses 20,000 years ago. And the broader field of research into ancient DNA has shed light on important moments in human history. Only recently did analyses of ancient genes uncover locations on the human genome associated with surviving Yersinia pestis – the bacterium that causes the bubonic plague. <h2>Single events probably triggered selection</h2> This study, published in Nature Ecology and Evolution, has similarly found environmental events might have been more influential on evolution among Eurasian groups. Such events might lead to a point of natural selection. Take, for instance, the emergence of a pathogen. If such a disease could kill people, those who managed to survive and continue reproducing would pass down favourable traits to subsequent generations. “Natural selection acts in two different mechanisms,” says Souilmi. “It only cares about whether you’re procreating successfully… when it acts, it’s either killing a lot of people, [preventing] some people from reproducing successfully, or some people are just not finding mates because they have some sort of ailment that’s not allowing them to mate successfully, or might make them undesirable. “What we’re finding is that the signal of natural selection we detected in this [research] was likely a single event, because the signal is clustered in time in a very early migration out of Africa. “Not all of the [events] we detected occurred at the same time, but the bulk of them did.” <h2>A mirror to the present</h2> This ‘agnostic’ study did not seek to identify the external pressures leading to the selection events indicated in these ancient genes, but future research by the team will seek to uncover that information. Studies like this, or those into specific pressures like the influence of the Black Death or coronaviruses on humans, show the impact of environmental change on our genetics. Souilmi says this is both insightful and cautionary, as environmental change in the present could be studied by humans in the future. He speculates that changes in the Earth’s climate, or the emergence of new pathogens, likely imposed selection pressures on ancient groups, whether through forcing shortages or changes to food supply or imposing physiological stressors. “Very likely, it’s the environment, the temperature, the weather patterns, that would have somewhat impacted the dietary regime of our ancestors out of Africa, and pathogens would have driven this [genetic] adaptation, which has shaped our genetic diversity now,” Souilmi says. “The direct lesson, socially, now, is that if we’re ever faced with events that are similar to that, we are not as immune to extreme episodes of adaptation where a lot of people might die, or be unable to reproduce. “Unless we do something to counteract the environmental changes, or viruses, bacterial or other pandemics, it could be a bad thing.” This article originally appeared on <a href="https://cosmosmagazine.com/science/human-evolution-driven-by-environment/" target="_blank" rel="noopener">cosmosmagazine.com</a> and was written by Matthew Agius. Image: Shutterstock

Body

Big study shows that lowering blood pressure lowers risk of dementia

A study across 20 countries has strengthened a link between lowering blood pressure, and reducing the risk of dementia. The meta-analysis, published in the European Heart Journal, draws on clinical trial data from 28,008 participants, to show the strongest link to date between medication that lowers blood pressure, and reduced dementia risk. “We know that high blood pressure is a risk factor for dementia – especially high blood pressure in midlife, so say 40 to 65 years of age,” says lead author Dr Ruth Peters, an associate professor at the University of New South Wales and program lead for dementia in the George Institute’s Global Brain Health Initiative. “But there has been some uncertainty about whether lowering blood pressure, especially in older adults, would reduce risk of dementia. “What we’ve done is take five really high-quality clinical trials and combine them into one dataset, which gave us the ability to really look at this question and look at the relationship between blood pressure-lowering tablets – antihypertensives – and dementia.” The five studies were all double-blind, randomised clinical trials – the ‘gold standard’ in medical research – with participants hailing from 20 different countries. The average age of the participants was 69, and participants were followed up an average of four years after doing the trial. Participants who took antihypertensives had a significantly lower chance of being diagnosed with dementia than those who took placebos. Dementia affects 50 million people worldwide: a number projected to triple by 2050. According to The Lancet’s 2020 Commission on dementia, treatment for hypertension (high blood pressure) is “the only known effective preventive medication for dementia,” all other methods of reducing your risk come from lifestyle and environment. “The strength of this study is the use of individual patient data in a meta-analysis of data drawn from randomised controlled trials of blood pressure medication. This is the first time such data has been meta-analysed,” says Professor Kaarin Anstey, a senior principal research scientist at Neuroscience Research Australia and the UNSW. “This is important for informing clinical practice,” adds Anstey, who was not involved with the study. Professor Nicolas Cherbuin, head of the Australian National University’s Centre for Research on Ageing, Health and Wellbeing, says that the study is “well-designed”, and reflects research by his team showing that higher blood pressure is linked to lower brain volumes and poorer brain health. “The diagnostic procedure and criteria used are well-established, the sample size is large, those with dementia at baseline were excluded,” says Cherbuin. But he points out that the study didn’t find an effect of blood pressure medication on cognitive decline, and nor did it include participants with mild cognitive impairment, who would be “more likely to convert”. Anstey points out that “inevitably” the participants in the cohort are now quite old, and thus may be different to populations developing dementia now. “Clinical trials involve highly selected samples and often exclude diverse ethnic groups,” she adds. “I hope that this reinforces the importance of blood pressure control for brain health,” says Peters. But she emphasises that, while this is useful news for preventing dementia in mid-life, people of all ages can improve their brain health by other means. “It’s not just blood pressure lowering – it has to be taken in the context of a healthy lifestyle.” This article originally appeared on <a href="https://cosmosmagazine.com/health/dementia-blood-pressure-meta/" target="_blank" rel="noopener">cosmosmagazine.com</a> and was written by Ellen Phiddian. Image: Shutterstock

Body

Grace under pressure: Princess Kate heckled in Ireland

Princess Kate was the subject of a heckler in Northern Ireland, where she was greeting crowds after visiting a suicide prevention charity. Footage has emerged of the Princess of Wales shaking hands with the heckler, who filmed herself telling the royal that “Ireland belongs to the Irish”. “Nice to meet you but it would be better if it was when you were in your own country,” the woman said. The princess laughed off the comments before letting go of the woman’s hand and continuing to greet other members of the crowd. <blockquote class="twitter-tweet"> This woman reefing the arm off Kate Middleton and telling her 'Ireland belongs to the Irish'.... <a href="https://t.co/KK2gAqZ0Kv">pic.twitter.com/KK2gAqZ0Kv</a> — Caolán Mc Aree (@Caolanmcaree) <a href="https://twitter.com/Caolanmcaree/status/1578095529233641472?ref_src=twsrc%5Etfw">October 6, 2022</a></blockquote> Northern Ireland has been a hotly contested region since 1922, when the southern part of the country become gained independence and became the Republic of Ireland while Northern Island remained in the United Kingdom. Despite the tense interaction, Princess Kate’s time in Belfast seemed quite successful, as she and her husband Prince William visited several cross-community support organisations. Earlier in the day, the royal was spotted making and enjoying a cheeky drink with her husband after the couple travelled to the city centre to view the new outdoor street food and retail market. <img src="https://oversixtydev.blob.core.windows.net/media/2022/10/kate-belfast.jpg" alt="" width="1280" height="720" /> Kate Middleton was spotted trying her hand at cocktail making during her visit to Belfast, Northern Island. Image: Getty Images The market, which opened in July, was designed as a place for the community to come together to enjoy artisanal food and local products. The pair also met with workers from PIPS, a suicide prevention charity, and spoke to them about their work helping people at risk of suicide and self-harm. During their visit, the charity arranged for William and Kate to take part in an art therapy session, which saw them paint pumpkins with children whom PIPS has supported. Images: The Sun, Getty Images

Travel Trouble

Scientists have mimicked an embryo’s heart to unlock the secrets of how blood cells are born

Stem cells are the starting point for all other cells in our bodies. The <a href="https://www.eurostemcell.org/blood-stem-cells-pioneers-stem-cell-research" target="_blank" rel="noopener">first such cells to be found</a> were blood stem cells – as the name suggests, they give rise to different types of blood cells. But there’s much we don’t know about how these cells develop in the first place. In a study published today in <a href="https://doi.org/10.1016/j.celrep.2022.111339" target="_blank" rel="noopener">Cell Reports</a>, we have shown how a lab simulation of an embryo’s beating heart and circulation lead to the development of human blood stem cell precursors. The tiny device mimics embryonic blood flow, allowing us to directly observe human embryonic blood formation under the microscope. These results may help us understand how we can produce life-saving therapies for patients who need new blood stem cells. <h2>Growing life-saving therapies in the lab</h2> To treat aggressive blood cancers such as leukaemia, patients often need extremely high doses of chemotherapy; a <a href="https://www.cancer.nsw.gov.au/myeloma/diagnosis-and-treatment/treatment/types-of-treatment/stem-cell-transplant#:%7E:text=A%20stem%20cell%20transplant%20involves%20killing%20blood%20cells,they%20are%20collected%20beforehand%20and%20kept%20in%20storage." target="_blank" rel="noopener">blood stem cell transplant</a> then regenerates blood after the treatment. These are life-saving therapies but are restricted to patients who have a suitable tissue-matched donor of blood stem cells. A way around this problem would be to grow more blood stem cells in the lab. Unfortunately, past experiments have shown that harvested adult blood stem cells lose their transplantation potential if grown in the lab. The discovery of <a href="https://en.wikipedia.org/wiki/Induced_pluripotent_stem_cell" target="_blank" rel="noopener">induced pluripotent stem cells</a> – stem cells made out of adult cells – in 2006 led to a promising new approach. Induced pluripotent stem cells are made from the patient’s own cells, so there is no problem with tissue rejection, or the ethical issues surrounding the use of IVF embryos. These cell lines are similar to embryonic stem cells, so they have the potential to form any tissue or cell type – hence, they are “pluripotent”. In theory, pluripotent stem cell lines could provide an unlimited supply of cells for blood regeneration because <a href="https://en.wikipedia.org/wiki/Immortalised_cell_line" target="_blank" rel="noopener">they are immortalised</a> – they can grow in the lab indefinitely. But the development of processes to allow us to grow particular types of tissues, organs and cell types – such as blood – has been slow and will take decades to advance. One must mimic the complex process of embryogenesis in the dish! <h2>Engineering an embryonic heart</h2> Current understanding of how embryonic blood stem cells develop is based on animal models. Experiments with anaesthetised zebrafish embryos have shown that blood stem cells arise in the wall of <a href="https://pubmed.ncbi.nlm.nih.gov/20154733/" target="_blank" rel="noopener">the main blood vessel, the aorta</a>, shortly after the first heartbeat. For ethical reasons, it’s obvious this type of study is not possible in human embryos. This is why we wanted to engineer an embryonic heart model in the lab. To achieve this, we used <a href="https://www.elveflow.com/microfluidic-reviews/general-microfluidics/a-general-overview-of-microfluidics/" target="_blank" rel="noopener">microfluidics</a> – an approach that involves manipulating extremely small volumes of liquids. The first step in generating blood stem cells from pluripotent stem cells is to coax the latter to form the site where blood stem cells start growing. This is known as the AGM region (aorta-gonad-mesonephros) of the embryo. Our miniature heart pump and circulation (3 by 3 centimetres) mimics the mechanical environment in which blood stem cells form in the human embryo. The device pumps culture media – liquids used to grow cells – around a microfluidic circuit to copy what the embryo heart does. <h2>A step closer to treatment</h2> Once we got the cells to form the AGM region by stimulating cells on day two of starting our cell culture, we applied what’s known as pulsatile circulatory flow from day 10 to day 26. Blood precursors entered the artificial circulation from blood vessels lining the microfluidic channels. Then, we harvested the circulating cells and grew them in culture, showing that they developed into various blood components – white blood cells, red blood cells, platelets, and others. In-depth analysis of gene expression in single cells showed that circulatory flow generated aortic and blood stem precursor cells found in the AGM of human embryos. This means our study has shown how pulsatile circulatory flow enhances the formation of blood stem cell precursors from pluripotent stem cells. It’s knowledge we can use in the future. The next step in our research is to scale up the production of blood stem cell precursors, and to test their transplant potential in immune-deficient mice that can accept human transplants. We can do this by using large numbers of pluripotent stem cells grown in bioreactors that also mechanically stimulate blood stem cell formation. If we can easily produce blood stem cells from pluripotent stem cell lines, it would provide a plentiful supply of these cells to help treatments of cancer or genetic blood diseases. This article originally appeared on <a href="https://theconversation.com/scientists-have-mimicked-an-embryos-heart-to-unlock-the-secrets-of-how-blood-cells-are-born-190530" target="_blank" rel="noopener">The Conversation</a>. Image: UNSW

Body

"She sat on a throne of blood": Uni professor launches another attack on Queen Elizabeth

A controversial university professor has doubled down on her celebration of Queen Elizabeth's death, claiming she "sat on a throne of blood". Uju Anya, a linguistics professor at Pennsylvania's Carnegie Mellon University, <a href="https://www.oversixty.co.nz/news/news/uni-professor-slammed-for-wishing-the-queen-excruciating-pain" target="_blank" rel="noopener">came under fire</a> earlier this week for a series of controversial tweets in which she hoped the Queen was in "excruciating pain" as she died. Now, the Nigerian-American lecturer has reiterated her claims on a podcast, saying, "This was a ruler. The very crown she had on her head signified the fact that she's a monarch was made from plunder. Diamonds. Blood diamonds." "The throne that she was sitting on is a throne of blood... Her very position as a monarch, the palace she lived in... were all paid for by our blood." She stood by her controversial tweets, which she admitted were an "emotional outburst", but said, "I said what I f****** said." "I was triggered by this news. It went deep into pain and trauma for me. Due to my family experience with the rule of this monarch." Anya also shared her thoughts on the Queen's role in the Nigerian Civil War in 1967 by showing support for the turbulent government. She said, "People expected me to be calm or to be... when the person who literally paid money for bombs and guns and military supplies to come and massacre your people is dying, you're not supped to dance." Anya's claims forced her employer to say in a statement, "We do not condone the offensive and objectionable messages posted by Uju Anya today on her social media account." "Free expression is core to the mission of higher education. However, the views she shared absolutely do not represent the values of the institution, nor the standards of discourse we seek to foster," they concluded. Despite thousands of people being up in arms over her comments and demanding an apology, others have jumped to the professor's defence. Over 4,000 people have signed a petition defending Anya, saying her posts on Twitter spoke to personal anguish the scholar still feels about atrocities by the British Empire decades ago that touched her family. Refusing to apologise, Anya once again tweeted, "If anyone expects me to express anything but disdain for the monarch who supervised a government that sponsored the genocide that massacred and displaced half my family and the consequences of which those alive today are still trying to overcome, you can keep wishing upon a star." Image credits: Getty Images / Youtube

Caring

Anne Heche's blood test results revealed after horror smash

An investigation of Anne Heche’s blood results have detected “the presence of drugs” following <a href="https://www.oversixty.com.au/news/news/new-details-of-actor-anne-heche-s-fiery-crash" target="_blank" rel="noopener">her horror smash</a>. The US actress was pulled out of her burning car after she smashed into a mansion in Los Angeles while driving a terrifying 140km/h on August 5. The 53-year-old suffered severe injuries and soon after the crash fell into a coma and has not regained consciousness since. Almost a week after the incident, a Los Angeles Police Department Public Information Officer confirmed there was a “presence of drugs” in Anne’s blood system. “Based on the blood draw, it revealed the presence of drugs, however additional testing is required to rule out any substances that were administered at the hospital as part of her medical treatment,” they told <a href="https://www.foxnews.com/entertainment/anne-heche-blood-test-revealed-presence-of-drugs" target="_blank" rel="noopener">Fox News Digital</a>. "Any secondary drugs [takes] up to 30 days for [a] secondary test to come back.” TMZ previously reported that Anne had cocaine in her system upon arrival at the hospital, but that is yet to be confirmed. The crash is currently being investigated by the LAPD who have confirmed that if Anne is found to have been drunk she would face significant charges. "If found intoxicated, [Heche] could be charged with misdemeanour DUI hit and run. No arrests have been made so far,” a representative said. Anne’s representative has confirmed that she is in an “extreme critical condition”. “She has a significant pulmonary injury requiring mechanical ventilation and burns that require surgical intervention,” her representative said. “She is in a coma and has not regained consciousness since shortly after the accident.” Image: Getty

Caring

Bride wears engagement ring with blood in it

A bride-to-be has caused quite a stir after sharing a photo of her engagement ring that apparently has her fiancé’s blood in it. The woman shared the photo to the popular Facebook group “That's it, I'm wedding shaming” and at first glance it looks like a normal ring with a red stone. To everyone’s shock, she revealed that the “red stone” was in fact her fiancé’s blood. “Has anyone else opted out of a wedding band? I love my engagement ring so much, it has my fiancé’s blood in it and it is so special to me,” she began. “I’d rather that be put on my finger at the wedding instead of a band. I would have to get a custom one to fit my ring and I don’t know, I just don’t want to.” However, the comments were not nice about the $300 ring, with many questioning why anyone would do that. “I’m glad she loves it and is happy. It is heinous though,” one wrote. “I’m fine with one ring…as long as it’s not filled with BLOOD! What in the actual f**k?” someone else commented. "I hate it here," another simply wrote. Image: Facebook

Relationships

Man donates blood an incredible 600 times

A man has made an extraordinary accomplishment of saving more than 1,800 lives after donating blood 600 times. Bruce from Port Macquarie was egged on by his Aunty Mary after she had donated blood 70 times saying he would not be able to do as much as she did. But, Bruce being Bruce, he decided to accept his aunt's challenge and went ahead to donate blood. “My Aunty Mary told me she had done 70 donations, and that I would never catch her,” he said. “Smart lady, that one and the challenge was accepted.” Bruce, 60, now skateboards to an Australian Red Cross donation centre every fortnight to give generously. Since starting his blood donation, Bruce has become the first person in Port Macquarie – and one of only 60 people in Australia – to have donated blood a whopping 600 times. All those blood donations have contributed to saving the lives of up to 1,800 people including new mothers, babies, cancer patients and trauma sufferers. When asked for advice and encouragement on the process of donating, Bruce explained that it was a rewarding experience. “The vampires at [Lifeblood] are lovely and it doesn't hurt much at all, so I encourage others to put something back, roll up your sleeves and save a life,” he said. Bruce commended his Aunty Mary, saying that without her support he would not have reached the incredible milestone. Image: Australian Red Cross Lifeblood

Body

Genetic mutations slowly accumulated over a lifetime change blood production after 70 years of age

Ageing is likely caused by the gradual accumulation of molecular damage, or genetic mutations, in the cells of our bodies that occurs over a lifetime. But how this translates into the rapid deterioration in organ function that’s seen after the age of 70 has so far not been clear. Now, scientists have discovered that the accumulation of genetic mutations in blood stem cells are likely responsible for the abrupt change in how <a class="spai-bg-prepared" href="https://cosmosmagazine.com/science/biology/why-do-we-have-blood/" target="_blank" rel="noreferrer noopener">blood</a> is produced in the body after 70 years of age. The <a class="spai-bg-prepared" href="https://www.nature.com/articles/s41586-022-04786-y" target="_blank" rel="noreferrer noopener">new study</a>, published in Nature, points to a change in the diversity of stem cells that produce blood cells as the reason why the prevalence of reduced cell regeneration capacity, <a class="spai-bg-prepared" href="https://www.frontiersin.org/articles/10.3389/fonc.2020.579075/full" target="_blank" rel="noreferrer noopener">cytopenia</a> (one or more blood cell types is lower than it should be), immune disfunction, and risk of blood cancer dramatically rises after 70. “We’ve shown, for the first time, how steadily accumulating mutations throughout life lead to a catastrophic and inevitable change in blood cell populations after the age of 70,” says joint-senior author Dr Peter Campbell, head of the Cancer, Ageing and Somatic Mutation Program at the Wellcome Sanger Institute, UK. “What is super exciting about this model is that it may well apply in other organ systems too.” Blood cells are made in a process called haematopoiesis All of the cells in our blood – including red cells, white cells and platelets – develop in a process called haematopoiesis from haematopoietic stem cells in our bone marrow. These stem cells are what’s known as multipotent progenitor cells, which simply means that they can develop into more than one cell type. Researchers were interested in better understanding how this process changes as we age, so they sequenced the entire genomes of 3,579 haematopoietic stem cells from a total of 10 people – ranging in age from newborn to 81 years. <div class="newsletter-box spai-bg-prepared"> <div id="wpcf7-f6-p193434-o1" class="wpcf7 spai-bg-prepared" dir="ltr" lang="en-US" role="form"> </div> </div> Using this information, they were able to construct something similar to a family tree (<a class="spai-bg-prepared" href="https://www.nature.com/scitable/topicpage/reading-a-phylogenetic-tree-the-meaning-of-41956/#:~:text=A%20phylogenetic%20tree%2C%20also%20known,genes%20from%20a%20common%20ancestor." target="_blank" rel="noreferrer noopener">a phylogenetic tree</a>) for each stem cell, showing how the relationships between blood cells changes over the human lifespan. They found that in adults under 65, blood cells were produced from between 20,000 and 200,000 different stem cells – each contributing roughly equal amounts to production. But after 70 years of age they observed a dramatic decrease in the diversity of stem cells responsible for haematopoiesis in the bone marrow. In fact, only 12-18 independent expanded sets of stem cell clones accounted for 30-60% of cell production. These highly active stem cells had outcompeted others and progressively expanded in numbers (clones) across that person’s life, and this expansion (called <a class="spai-bg-prepared" href="https://www.nature.com/articles/s41586-022-04785-z" target="_blank" rel="noreferrer noopener">clonal haematopoiesis</a>) was caused by a rare subset of mutations known as driver mutations that had occurred decades earlier. “Our findings show that the diversity of blood stem cells is lost in older age due to positive selection of faster-growing clones with driver mutations. These clones ‘outcompete’ the slower growing ones,” explains lead researcher Dr Emily Mitchell, a haematology registrar at Addenbrooke’s Hospital,UK, and PhD student at the Wellcome Sanger Institute, US. “In many cases this increased fitness at the stem cell level likely comes at a cost – their ability to produce functional mature blood cells is impaired, so explaining the observed age-related loss of function in the blood system.” Which clones became the dominant stem cells varied between individuals, which explains why variation is seen in disease risk and other characteristics in older adults. “Factors such as chronic inflammation, smoking, infection and chemotherapy cause earlier growth of clones with cancer-driving mutations. We predict that these factors also bring forward the decline in blood stem cell diversity associated with ageing,” says joint-senior author Dr Elisa Laurenti, assistant professor at the Wellcome-MRC Cambridge Stem Cell Institute, UK. “It is possible that there are factors that might slow this process down, too,” she adds. “We now have the exciting task of figuring out how these newly discovered mutations affect blood function in the elderly, so we can learn how to minimise disease risk and promote healthy ageing.” <img id="cosmos-post-tracker" class="spai-bg-prepared" style="opacity: 0; height: 1px!important; width: 1px!important; border: 0!important; position: absolute!important; z-index: -1!important;" src="https://syndication.cosmosmagazine.com/?id=193434&title=Genetic+mutations+slowly+accumulated+over+a+lifetime+change+blood+production+after+70+years+of+age" width="1" height="1" /> <div id="contributors"> <a href="https://cosmosmagazine.com/science/mutations-change-blood-production/" target="_blank" rel="noopener">This article</a> was originally published on <a href="https://cosmosmagazine.com" target="_blank" rel="noopener">Cosmos Magazine</a> and was written by <a href="https://cosmosmagazine.com/contributor/imma-perfetto" target="_blank" rel="noopener">Imma Perfetto</a>. Imma Perfetto is a science writer at Cosmos. She has a Bachelor of Science with Honours in Science Communication from the University of Adelaide. Image: Getty Images </div>

Body

How often should I check my blood pressure?

A new study investigating the role of hypertension in a person’s risk of severe COVID-19 symptoms suggests that the condition may worsen symptoms due to its association with one particular factor. Hypertension, commonly known as high blood pressure, affects 1 in 3 Australian adults and 1 in 5 New Zealanders, according to the<a href="https://www.health.gov.au/ministers/the-hon-greg-hunt-mp/media/taking-the-pressure-off-high-blood-pressure" target="_blank" rel="noopener"> Australian Institute of Health and Welfare</a> and <a href="https://www.southerncross.co.nz/group/medical-library/high-blood-pressure-hypertension#:~:text=Known%20medically%20as%20hypertension%2C%20high,attack%20have%20high%20blood%20pressure." target="_blank" rel="noopener">Southern Cross NZ</a>, with men being more likely to have the condition. The study, published in <a href="https://doi.org/10.1007/s40292-022-00506-9" target="_blank" rel="noopener">PubMed</a>, concluded that hypertension doesn’t play an independent role in the severity of Covid symptoms from current evidence, but that systolic blood pressure, one the measurements used to determine blood pressure, could be a contributing factor. In light of these findings, the theme for this year’s World Hypertension Day, held on May 17, is Measure Your Blood Pressure Accurately, Control It, Live Longer in a bid to raise awareness of the condition, which can have no immediate symptoms. Andria Aird, a hypertension expert and Blooms the Chemist pharmacist, tells OverSixty that this absence of symptoms - except for headaches in severe cases - is why raising awareness is crucial, and why Blooms the Chemist is promoting free blood pressure checks this month. <img src="https://oversixtydev.blob.core.windows.net/media/2022/05/andria-aird.jpg" alt="" width="1280" height="720" /> Andria Aird says getting our blood pressure checked is key to detecting high blood pressure. Image: Supplied “Current surveys estimate that 32 percent of men and 27 percent of women in Australia have hypertension,” she says. “Left untreated, hypertension can increase your risk of life-threatening conditions like diabetes, heart attack and stroke.” This condition is particularly common among older adults, which Aird says is to do with the changes that occur in our blood vessels. “The walls of our arteries become stiffer and we are more at risk of high blood pressure,” she explains. “More mature people are also more at risk of other health conditions which often go hand in hand with hypertension.” Could I have hypertension and not know it? With no obvious symptoms, we can have hypertension without realising - and getting a blood pressure check is one of the ways to determine if we do. “Sometimes people come into our pharmacy to have their blood pressure tested and shown a systolic reading of up to 200 mmHg without even knowing it.” According to <a href="https://www.mayoclinic.org/diseases-conditions/high-blood-pressure/symptoms-causes/syc-20373410#:~:text=High%20blood%20pressure%20(hypertension)%20is,problems%2C%20such%20as%20heart%20disease." target="_blank" rel="noopener">Mayo Clinic</a>, high blood pressure is determined by the amount of blood your heart pumps and the amount of resistance to blood flow (or width) in your arteries. Blood pressure readings, given in millimetres of mercury (mmHg), consist of two numbers: systolic pressure (the pressure in your arteries when your heart beats) and diastolic pressure (the pressure in your arteries in-between beats). A healthy reading is considered to be a systolic pressure of 140 mmHg or less, and a diastolic pressure of less than 90 mmHg, according to the <a href="https://www.nia.nih.gov/health/high-blood-pressure-and-older-adults#:~:text=Normal%20blood%20pressure%20for%20most,pressure%20of%20less%20than%2080" target="_blank" rel="noopener">National Institute of Ageing</a>. As for how often we should be getting checked, Aird suggests over -50s rolling up their sleeves every 3-6 months. “At Blooms the Chemist we recommend all Australian adults have their blood pressure checked,” she says. “The Heart Foundation recommends at least every two years from 18 years, although my conservative recommendation for people over 50 would be at least 3 – 6 monthly. “Hypertension is not only a disease of the elderly, however those over 60 are at a higher risk.” But you don’t always have to go to the GP or chemist to get checked. “Reliable home blood pressure monitors are relatively affordable and easy to use. At Blooms The Chemist we can offer advice to recommend a monitor to suit your needs,” Aird says. As well as getting checked, Aird says there are some things we can do in our day-to-day lives to reduce our chances of developing hypertension. “Fortunately, there are lifestyle options we can take to reduce our risk of high blood pressure, even if there is a family history of the condition,” she says. “It is vital to quit if you are a smoker. A healthy diet, weight control and regular exercise all substantially reduce your risk. Other tips include reducing salt in your diet, managing stress and reducing alcohol intake.” Image: Getty Images

Body

Detecting skin cancer with a blood test

A team of US researchers have found a way to diagnose skin cancer using blood tests. The researchers have shown in a lab-based study that melanoma cells can be detected in blood and plasma. If the test makes it through clinical trials, the researchers hope that it could one day be used to sidestep the invasive biopsies that are currently required to diagnose melanoma. The test uses melanoma-specific antibodies, and a device designed specifically to react them with blood. The device is called MelanoBean, and it works with microfluidics: manipulating tiny amounts of fluid to do interesting things that they don’t do in larger volumes. The test is described in a <a href="https://dx.doi.org/10.1002/anbr.202100083" target="_blank" rel="noreferrer noopener">paper</a> in Advanced NanoBiomed Research. <div class="newsletter-box"> <div id="wpcf7-f6-p188890-o1" class="wpcf7" dir="ltr" lang="en-US" role="form"> </div> </div> “This is the first comprehensive study of circulating tumour cells – or CTCs – to evaluate the efficacy of surgery using microfluidic systems in melanoma, including changes in the number of CTCs, CTC cluster configuration, and gene expression profiling,” says first author Dr Yoon-Tae Kang, a researcher at the University of Michigan, US. The researchers found that with their test, melanoma cells (CTCs) could be found in the blood of cancer patients at all stages of the disease – I through to IV. It could also identify whether any CTCs were hanging around in the blood of patients who’d had skin cancer surgery to get their cells removed. “CTCs have the potential to pinpoint treatment resistance and recurrence, and can be a valuable biomarker to non-invasively monitor for disease progression,” says corresponding author Dr Sunitha Nagrath also from the University of Michican. <img id="cosmos-post-tracker" style="opacity: 0; height: 1px!important; width: 1px!important; border: 0!important; position: absolute!important; z-index: -1!important;" src="https://syndication.cosmosmagazine.com/?id=188890&title=Detecting+skin+cancer+with+a+blood+test" width="1" height="1" data-spai-target="src" data-spai-orig="" data-spai-exclude="nocdn" /> <div id="contributors"> <a href="https://cosmosmagazine.com/health/medicine/detecting-skin-cancer-blood-test/" target="_blank" rel="noopener">This article</a> was originally published on <a href="https://cosmosmagazine.com" target="_blank" rel="noopener">Cosmos Magazine</a> and was written by <a href="https://cosmosmagazine.com/contributor/ellen-phiddian" target="_blank" rel="noopener">Ellen Phiddian</a>. Ellen Phiddian is a science journalist at Cosmos. She has a BSc (Honours) in chemistry and science communication, and an MSc in science communication, both from the Australian National University. Image: Getty Images </div>

Body

The heart-breaking way Ukrainian parents are keeping their kids safe

As the people of Ukraine brace for increasing military conflict from Russia, parents are taking every measure to keep their children safe. Parents in Ukraine have resorted to sending their children to school wearing stickers that list their blood types in case the worst happens while out of their parents' sight. On Monday, after President Vladimir Putin gave a speech in which he “recognised the independence” of two separatist, pro-Russia regions of eastern Ukraine - an act Kyiv’s mayor described as a declaration of war - many parents started sending their children to school with special stickers. Vasyl and Marta, whose last names are being withheld for their protection, took part in the protection measure when sending their two daughters, age 5 and 9, to school in their village 15 kilometres from the Ukrainian capital of Kyiv. “It’s like a piece of paper, with blood type information, the names of their parents, and telephone numbers,” Vasyl tells Today via phone. “There is no one form for such a sticker. It depends on every parent. It’s up to them.” Mothers in the Ukraine started discussing the sticker system in closed Facebook groups after Putin's speech in order to do what they could to ensure the safety of their kids. “This was a debate in one of (many) closed groups on Facebook,” Olga Tokariuk, a Kyiv-based freelance correspondent, tells Today. “Some schools actually made these stickers mandatory.” Ukrainian mother Khrystyna has also had several safety conversations with her three daughters, making sure her 3 and 5 year olds know their address, their first and last names, and their mother’s full name. “What they know is that, ‘You should listen to your mum and do what she says.’ And if I said, ‘We go with me’ —because you know, kids want to do what they want — I said, ‘No, you do what I say, and that’s it. And if you should hear loud noises, you listen to me very carefully.’” While Khrystyna is continuing to send her 13-year-old to school, she is keeping her two youngest daughters home. "We pray a lot,” she said. “We just pray for peace.” Image credits: Getty Images

Caring

Toxic positivity: societal pressure to feel good could have the opposite effect

<div class="copy"> <a href="https://www.nature.com/articles/s41598-021-04262-z" target="_blank" rel="noreferrer noopener">A multi-national study</a> of 40 countries has found that the societal pressure to feel good is linked to poorer wellbeing in individuals. In almost all countries, experiencing pressure to be happy and not sad was related to more and stronger negative feelings, and stronger symptoms of depression, anxiety, and stress. Interestingly, this relationship was almost twice as strong in countries with higher national happiness, compared to those with lower national happiness – suggesting it may have downsides for some members of society. “The level of happiness individuals feel pressured to achieve may be unattainable and reveal differences between an individual’s emotional life and the emotions society approves of,” says lead author Dr Egon Dejonckheere from the Faculty of Psychology and Educational Sciences at KU Leuven, Belgium, and assistant professor in the Department of Medical and Clinical Psychology at Tilburg University in the Netherlands. “This discrepancy between an individual and society may create a perceived failure that can trigger negative emotions,” he explains. “In countries where all citizens appear to be happy, deviations from the expected norm are likely more apparent, which makes it more distressing.” The international team of scientists, including Australian researchers from the University of Melbourne, investigated how the perceived societal pressure to be happy predicts emotional, cognitive, and clinical indicators of wellbeing in a survey of nearly 7,500 people. Published in Springer Nature, the study then went a step further to evaluate the role of the nations’ global happiness levels on the relationship between societal pressure and wellbeing, using their World Happiness Index (WHI) scores. This score is taken from the <a href="https://worldhappiness.report/" target="_blank" rel="noreferrer noopener">World Happiness Report</a> and is a measure of the average self-reported life satisfaction displayed by inhabitants of a particular country. Countries included in the study that were rated as having higher happiness in the World Happiness Index included The Netherlands and Canada, while countries rated with lower happiness included Uganda and Senegal. As a <a href="https://www.verywellmind.com/what-is-a-cross-sectional-study-2794978#:~:text=A%20cross%2Dsectional%20study%20involves,one%20specific%20point%20in%20time.&text=This%20method%20is%20often%20used,support%20further%20research%20and%20experimentation." target="_blank" rel="noreferrer noopener">cross-sectional study</a>, the researchers acknowledge that while these findings can highlight a correlation between these factors, it cannot prove causality. Nonetheless, they do suggest that changing societal discourse from promoting a one-sided embrace of emotions to one where people learn to appreciate the full scope of their emotional lives (both positive and negative), could have beneficial effects for people’s psychological well-being in the long run. Image credits: Getty Images <img id="cosmos-post-tracker" style="opacity: 0; height: 1px!important; width: 1px!important; border: 0!important; position: absolute!important; z-index: -1!important;" src="https://syndication.cosmosmagazine.com/?id=182523&title=Toxic+positivity%3A+societal+pressure+to+feel+good+could+have+the+opposite+effect" width="1" height="1" data-spai-target="src" data-spai-orig="" data-spai-exclude="nocdn" /></div> <div id="contributors"> This article was originally published on <a href="https://cosmosmagazine.com/health/body-and-mind/toxic-positivity-societal-pressure-to-feel-good-could-have-the-opposite-effect/" target="_blank" rel="noopener">cosmosmagazine.com</a> and was written by Imma Perfetto. </div>

Mind

Peer pressure driving sustainable diets

Image: Getty <div> <div class="copy"> People find it notoriously difficult to change eating habits to improve their own health, let alone the planet’s. Now European researchers who explored factors that might motivate shifts to more sustainable diets are suggesting that social norms and self-efficacy are the most important. The work by Sibel Eker and Michael Obersteiner, from the International Institute for Applied Systems Analysis in Austria, and Gerhard Reese, from Germany’s University of Koblenz-Landau, supports evidence that peer group values are more powerful than scientific facts in shaping people’s beliefs and actions about climate change. Their findings are presented in a paper in the journal Nature Sustainability. The study was motivated by increasing calls for people to adopt plant-based diets as part of radical shifts needed to address the destructive impact of current farming practices on the environment. A key target is red meat, which vastly exceeds other food sources in terms of its land use, irrigation and greenhouse gas emissions, and is unsustainable in the face of population growth and climate change. Red meat also has been associated with chronic health conditions, including diabetes, heart disease and some cancers. On this front alone, calculations suggest that if, on average, the world adopted a flexitarian diet (one portion of red meat per week), it could potentially prevent more than 10 million deaths each year. Eker wondered if such “ambitious scenarios” were attainable. “I was observing my social network and society,” she says, “like more and more people being meat-reducers, new vegetarian restaurants in urban areas, and it made me curious about where these dynamics could lead.” Although many people are reducing their meat intake in several countries, widespread resistance means that global levels needed to translate into environmental gains are still beyond reach. To explore how pervasive behavioural changes in meat consumption might be achieved, Eker and colleagues used an integrated assessment model to simulate population dynamics. Based on prominent psychological theories on environmental action, combined with models from management science, it includes income, social norms, climate risk perception, health risk perception, self-efficacy and response efficacy (belief that one’s actions can make a difference), as well as age, gender and education level. They simulated the model 10,000 times to find the optimal outcome. “This was an exploratory modelling study,” explains Eker, “meaning that we used the model as a platform to experiment with different scenarios to find the most important drivers of diet shifts.” Although she expected concern about health risks to be more important, Eker was not surprised that social norms – unwritten rules of behaviour considered acceptable in a group or society – were a leading motivator of diet change, because they create a strong, positive feedback loop, she says. Put differently, “As there are more vegetarians around, visibility of the phenomenon increases, therefore adoption increases”. The other key driver was self-efficacy, particularly in females, referring to perceived control over one’s behaviour and ability to change. Results showed that this model would yield the most rapid behaviour changes for people aged 15 to 44 years, even when their adoption of vegetarian diets is low. But even if 40% of the population became vegetarian, the model predicted that the environmental benefits may not be fully realised if everyone else continues their current meat consumption, suggesting that change requires a population-wide shift in eating patterns. The researchers conclude that their findings demonstrate the importance of factoring human behaviour into climate change mitigation efforts and suggest that future research also account for variations in cultural attitudes and world views. “We can use models to explore the social and behavioural aspects of climate change and sustainability problems in the same way as we explore the economic and environmental dimensions of our world,” says Eker. This could provide a better understanding of how to motivate the lifestyle changes that are essential to address the predicaments facing the planet. <div class="newsletter-box"> <div id="wpcf7-f6-p26085-o1" class="wpcf7">  </div> </div>  <img id="cosmos-post-tracker" style="opacity: 0; height: 1px!important; width: 1px!important; border: 0!important; position: absolute!important; z-index: -1!important;" src="https://syndication.cosmosmagazine.com/?id=26085&title=Peer+pressure+driving+sustainable+diets" alt="" width="1" height="1" /> </div> <div id="contributors"> <a href="https://cosmosmagazine.com/health/nutrition/peer-pressure-could-nudge-people-towards-sustainable-diets/">This article</a> was originally published on <a href="https://cosmosmagazine.com">Cosmos Magazine</a> and was written by <a href="https://cosmosmagazine.com/contributor/natalie-parletta">Natalie Parletta</a>. </div> </div>

Food & Wine

Confusion, financial pressure, discomfort: older people can struggle with sustainable living, despite its obvious benefits

Improving the sustainability of Australia’s housing stock is <a href="https://www.google.com/search?client=safari&rls=en&q=building+sector+australia+emissions+the+conversation&ie=UTF-8&oe=UTF-8">crucial</a> to meeting national emissions reduction goals. But for older adults, such changes can bring both benefits and challenges. My <a href="https://www.sciencedirect.com/science/article/abs/pii/S0360132321007344">recent research</a> examined the literature on environmental sustainability measures at residences for older adults. These included private homes, retirement villages and nursing homes. I found that while sustainability measures can bring multiple benefits to older people, they also bring challenges. For example, people living in sustainable dwellings may use less energy and water which leads to lower bills. But older people may suffer cognitive decline and struggle to use sustainable technology devices. The full effects of environmentally sustainable features must be better understood if we’re to provide seniors with high-quality residential environments. <img src="https://images.theconversation.com/files/441440/original/file-20220119-15-60lcsc.jpg?ixlib=rb-1.1.0&q=45&auto=format&w=754&fit=clip" alt="Older man walks down corridor" /> Sustainability measures can bring benefits and challenges to older people. Shutterstock <h2>Sustainability and ageing: a complex mix</h2> Forecasts suggest that by 2056, <a href="https://www.aihw.gov.au/reports-data/population-groups/older-people/overview">22% of Australians</a> – or 8.7 million people – will be aged 65 or older. High-quality residential environments are important to maintaining the welfare of these people as they age. Environmental sustainability is playing an ever greater role in residential development across the board, including retirement villages. And <a href="https://www.hindawi.com/journals/jar/2014/919054/">previous research</a> suggests most retirement village residents want to lead more sustainable lifestyles. As climate change worsens, the dwellings of older adults should allow them to adapt to these changing conditions. The reduced ability of elderly people to regulate their body temperature means global warming is a profound threat to this group. Improving the sustainability of a residential environment may include: <ul> <li>reducing waste</li> <li>using low carbon or recycled building materials</li> <li>solar passive design</li> <li>efficient heating and cooling</li> <li>using renewable energy such as rooftop solar.</li> </ul> <a href="https://new.gbca.org.au/case-studies/building/stockland-takes-sustainability-retirement-living/">Some residential projects</a> for the elderly already include environmental sustainability. A <a href="https://www.emerald.com/insight/content/doi/10.1108/F-08-2011-0060/full/html">case study</a> of a not-for-profit retirement village in South Australia revealed practices such as innovative floor plans, thermally efficient building materials, good window orientation and a water harvesting system. And my previous research <a href="https://www.sciencedirect.com/science/article/abs/pii/S0959652619341605">found</a> a range of sustainability features at eight private and not-for-profit retirement villages in Queensland. However, while many retirement village developers prioritise “social sustainability” features such as care provision and social interaction, environmental sustainability is <a href="https://www.sciencedirect.com/science/article/abs/pii/S0959652617313963">largely ignored</a>. <img src="https://images.theconversation.com/files/441450/original/file-20220119-25-1qtv5d.jpg?ixlib=rb-1.1.0&q=45&auto=format&w=754&fit=clip" alt="elderly woman holds hands of carer" /> Forecasts suggest that by 2056, 22% of Australians will be aged 65 or older. Shutterstock <h2>On the plus side</h2> The benefits of environmentally sustainable features in in older adults’ residential environment include: - reduced resource consumption: sustainable dwellings usually require less water and energy use, which lowers living costs. This is especially important for older adults who often have reduced financial capacity after retirement. Older people also use energy <a href="https://www.sciencedirect.com/science/article/abs/pii/S0301421597000402">more intensively</a> than other groups because they have fewer household members, greater heating requirements and spend more time at home. - reduced health risks: environmentally sustainable measures can lead to healthier indoor environments. For example, good ventilation and high-quality air conditioning often lead to improved indoor air quality and more comfortable ambient temperatures. - alleviated environmental challenges: many older people want their homes to be more environmentally friendly. Doing their bit to alleviate global problems such as greenhouse gas emissions can provide them with peace of mind. <img src="https://images.theconversation.com/files/441438/original/file-20220119-15-124namg.jpg?ixlib=rb-1.1.0&q=45&auto=format&w=754&fit=clip" alt="elderly person's hands on heater" /> Sustainable dwellings usually require less water and energy use, Shutterstock <h2>The potential downsides</h2> The challenges of environmentally sustainable home features for older adults include: - financial pressure: the income of many older adults is substantially reduced after retirement. This <a href="https://www.sciencedirect.com/science/article/abs/pii/S0301421511005222">can conflict</a> with the high initial investment of developing an sustainable housing and the cost of replacing existing systems with sustainable ones. - reducing energy consumption: in some cases, sustainability measures can involve tolerating slightly higher or cooler temperatures. For example, moving from a gas-heating system to a more sustainable type may <a href="https://www.sciencedirect.com/science/article/pii/S0301421515001172">delay</a> the arrival of heat in a room and leave older people uncomfortable for a short time. This may conflict with older people’s <a href="https://ideas.repec.org/a/eee/enepol/v84y2015icp250-256.html">increased sensitivity</a> to ambient temperatures. - confusion and complexity: Older adults can have <a href="https://academic.oup.com/bmb/article/92/1/135/332828">reduced cognitive capabilities</a> affecting memory and information processing speed. As a result they may struggle to use sustainable technologies such as smart thermostats. Research has <a href="https://www.sciencedirect.com/science/article/abs/pii/S0301421514006259">suggested</a> ways of overcoming this, such as better recognising the diversity of older adults to achieve a better “person-technology fit”. <img src="https://images.theconversation.com/files/441437/original/file-20220119-25-fkfanl.jpg?ixlib=rb-1.1.0&q=45&auto=format&w=754&fit=clip" alt="Four older women shelter from the sun under umbrella" /> Older people may have increased sensitivity to hot or cold temperatures. Paul Miller/AAP <h2>Next steps</h2> Older adults have unique needs which their homes <a href="https://www.sciencedirect.com/science/article/abs/pii/S0360132321007344">must satisfy</a>, even when sustainability features are being adopted. Ageing should be seen as a dynamic process with physical, psychological and social dimensions. And the complex interrelationships of ageing, environmental sustainability and the residential environment also need to be recognised. Best practices and lessons learned in creating sustainable living environments for older adults should be <a href="https://www.sciencedirect.com/science/article/abs/pii/S0959652618325241">shared</a>. Finally, developers making sustainability decisions should consult other stakeholders. These include contractors, occupational therapists, researchers and most importantly, older adults themselves.<img style="border: none !important; box-shadow: none !important; margin: 0 !important; max-height: 1px !important; max-width: 1px !important; min-height: 1px !important; min-width: 1px !important; opacity: 0 !important; outline: none !important; padding: 0 !important; text-shadow: none !important;" src="https://counter.theconversation.com/content/174535/count.gif?distributor=republish-lightbox-basic" alt="The Conversation" width="1" height="1" /> <a href="https://theconversation.com/profiles/xin-hu-685656">Xin Hu</a>, Lecturer, School of Architecture and Built Environment, <a href="https://theconversation.com/institutions/deakin-university-757">Deakin University</a> This article is republished from <a href="https://theconversation.com">The Conversation</a> under a Creative Commons license. Read the <a href="https://theconversation.com/confusion-financial-pressure-discomfort-older-people-can-struggle-with-sustainable-living-despite-its-obvious-benefits-174535">original article</a>. Image: Shutterstock

Retirement Income

"Poise under pressure": Woman snaps selfie as car sinks in ice

Image: Twitter A woman In Canada has been criticised for appearing to take a selfie from the roof of her submerged car as it sunk in a frozen lake. The woman’s car became submerged after breaking through ice on the Rideau River in Ottawa on Sunday afternoon, requiring her to be rescued. Ottawa Police tweeted that local residents had come to her aid using “a kayak and quick thinking”. Video obtained by 580 CFRA shows people rushing towards the woman with a kayak as she stands on top of her yellow car. <blockquote class="twitter-tweet"> NEW: Neighbours use kayaks to rescue driver after car crashes through ice in Manotick <a href="https://twitter.com/hashtag/ottnews?src=hash&ref_src=twsrc%5Etfw">#ottnews</a> <a href="https://t.co/dhANorovWK">https://t.co/dhANorovWK</a> — CTV Ottawa (@ctvottawa) <a href="https://twitter.com/ctvottawa/status/1482873513782525952?ref_src=twsrc%5Etfw">January 17, 2022</a></blockquote> Resident Zachary King told CTV News Ottawa he and his neighbour Rob Crober were the ones who rescued the woman. "It’s like everything worked out perfectly,” he told the station. “Got her on the kayak, pulled her in. And as soon as we pulled her in, the car went under. Fully." Video shot by resident Sacha Gera appears to show the woman driving on the ice at speed ahead of the rescue. It was reported that nobody was injured. Police said it served as an example that people should not drive across ice even when it looks safe. It seems the woman spent her time waiting to be rescued snapping a selfie while on the roof of her car. “She captured the moment with a selfie while people hurried and worried to help her,” Lynda Douglas tweeted, along with a photo. “Any time you are in a dangerous situation, you should not be taking selfies or doing anything distracting. You should be 100 per cent focused on being safe,” another man tweeted. However, others were far less critical. “She's waiting to be rescued. What the hell else is she supposed to do?” one man tweeted. “I appreciate her poise under pressure.” Regardless, the drive on the ice has proven costly for the woman, with her car being written off. Police have also charged her with an offence.

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"Poise under pressure": Woman snaps selfie as car sinks in ice

News

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Catalogues

Travel

Health

Lifestyle

Finance

Entertainment

Property

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Keep up to date

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Centenarian blood tests give hints of the secrets to longevity

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No, you can’t reverse ageing by injecting ‘young blood’ and fasting. But that doesn’t stop people trying

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Grace under pressure: Princess Kate heckled in Ireland

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"Poise under pressure": Woman snaps selfie as car sinks in ice

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